This proposed IIDS project will collaborate with different scholars who are experts in mental health, neuropsychology, and neuropsychiatry from Australia, Singapore, Hong Kong, Mainland China, the United States, and New Zealand, and will also establish partnerships with different local institutions such as Tung Wah College and non-local universities such as the Affiliated Brain Hospital of Guangzhou Medical University. Team members and keynote speakers from different local and non-local institutions will be engaged in promoting the conference and invitation of presentations within and beyond their affiliated institutions to increase the engagement of each institution involved. Specifically, this project will organize a two-day international conference on the theme of the neuropsychological mechanism of mental health across lifespan in the time of the COVID-19 pandemic. The two-day international conference will include eight plenary lectures, four oral sessions, and two poster sessions. The plenary lectures and oral sessions will involve a blend of empirical investigations and evidence-based practices from different approaches to facilitate intellectual exchanges between scholars and practitioners across various disciplines, thereby obtaining a better understanding of the neuropsychological mechanism of mental health in the face of pandemic as well as the efficacy of mental health and neuro-based interventions from developmental perspectives. At the end of each plenary lecture and oral session, there will be a panel discussion that will focus on the future development of integrated research and practice in fostering mental health across cultures and lifespans during and after the pandemic. There will be a breakfast reception and a professional connect hour on each conference day which helps strengthen the connections of local researchers and practitioners with the plenary speakers and international scholars to establish potential research collaborations for promoting neuropsychological well-being. This proposed IIDS project will benefit local and overseas scholars, students, and practitioners across various disciplines by enhancing the knowledge and understanding of how to promote mental health and neuropsychological functions from a developmental perspective. Interdisciplinary insights will be generated from in-depth and ongoing intellectual exchanges during and after the conference, helping scholars and practitioners to collaboratively develop rigorous scientific interdisciplinary research and potentially neuro-based mental health interventions. Ultimately, these measures can help prevent future mental health problems in different age groups as well as relieve the financial burden that was incurred during the time of the pandemic.